Details for gene set GOBP_DEFENSE_RESPONSE_TO

Table: GSEA Results Summary

Dataset	Skin.Skin.cls #Skin_20-29_versus_Skin_70-79.Skin.cls #Skin_20-29_versus_Skin_70-79_repos
Phenotype	Skin.cls#Skin_20-29_versus_Skin_70-79_repos
Upregulated in class	Skin_70-79
GeneSet	GOBP_DEFENSE_RESPONSE_TO_VIRUS
Enrichment Score (ES)	-0.5473387
Normalized Enrichment Score (NES)	-1.7436639
Nominal p-value	0.0
FDR q-value	0.29157287
FWER p-Value	0.599

Table: GSEA details [plain text format]
	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	RNF26	NA	86	0.402	0.0068	No
2	POLR3H	NA	120	0.388	0.0142	No
3	ZC3HAV1	NA	187	0.353	0.0204	No
4	EXOSC4	NA	406	0.298	0.0225	No
5	NPLOC4	NA	498	0.280	0.0267	No
6	MUL1	NA	594	0.267	0.0305	No
7	MIR708	NA	991	0.225	0.0279	No
8	TREX1	NA	1022	0.222	0.0319	No
9	PLA2G10	NA	1386	0.198	0.0294	No
10	IFNLR1	NA	1507	0.192	0.0311	No
11	OPRK1	NA	1648	0.186	0.0324	No
12	MAVS	NA	1660	0.185	0.0360	No
13	RNASE6	NA	1773	0.180	0.0377	No
14	GPATCH3	NA	2031	0.170	0.0365	No
15	RNF216	NA	2038	0.170	0.0399	No
16	TLR8	NA	2282	0.161	0.0388	No
17	IFNA1	NA	2361	0.159	0.0407	No
18	FCN3	NA	3020	0.139	0.0315	No
19	IFNA5	NA	3544	0.127	0.0245	No
20	DEFA3	NA	3793	0.122	0.0225	No
21	IFNK	NA	3805	0.122	0.0248	No
22	G3BP1	NA	3933	0.119	0.0249	No
23	IFNA14	NA	4134	0.115	0.0237	No
24	DDX21	NA	4497	0.109	0.0193	No
25	IFNL1	NA	4615	0.107	0.0193	No
26	APOBEC3A	NA	4708	0.106	0.0198	No
27	ATAD3A	NA	5194	0.099	0.0130	No
28	PHB2	NA	5558	0.093	0.0082	No
29	DMBT1	NA	5718	0.091	0.0072	No
30	IFNW1	NA	5751	0.091	0.0085	No
31	CD207	NA	5851	0.089	0.0085	No
32	AGBL4	NA	6313	0.083	0.0018	No
33	FADD	NA	6730	0.078	-0.0043	No
34	IFNA16	NA	6751	0.078	-0.0030	No
35	APOBEC1	NA	8003	0.064	-0.0247	No
36	IRF5	NA	9086	0.053	-0.0435	No
37	SAMHD1	NA	9320	0.051	-0.0467	No
38	IFNA7	NA	9597	0.049	-0.0508	No
39	PCBP2	NA	9674	0.048	-0.0512	No
40	IFNB1	NA	10936	0.037	-0.0736	No
41	MIR26B	NA	11103	0.036	-0.0759	No
42	IFNE	NA	11175	0.035	-0.0765	No
43	TLR7	NA	11447	0.033	-0.0808	No
44	BPIFA1	NA	11668	0.032	-0.0842	No
45	RNF135	NA	12365	0.027	-0.0964	No
46	RNASE2	NA	13753	0.019	-0.1216	No
47	IL23A	NA	13831	0.018	-0.1226	No
48	NLRP9	NA	14217	0.016	-0.1293	No
49	DEFA1	NA	14286	0.016	-0.1303	No
50	TRAF3	NA	14687	0.014	-0.1373	No
51	IFNA10	NA	14760	0.014	-0.1384	No
52	ADAR	NA	14814	0.014	-0.1391	No
53	UNC93B1	NA	14949	0.013	-0.1413	No
54	DEFA1B	NA	15188	0.012	-0.1454	No
55	IFNA8	NA	17479	0.003	-0.1875	No
56	ANKRD17	NA	17909	0.002	-0.1953	No
57	RELA	NA	18032	0.001	-0.1975	No
58	PYCARD	NA	22400	-0.000	-0.2779	No
59	HYAL2	NA	22457	-0.001	-0.2789	No
60	ABCC9	NA	22995	-0.004	-0.2887	No
61	HSP90AA1	NA	23170	-0.005	-0.2918	No
62	TKFC	NA	23194	-0.006	-0.2921	No
63	GPAM	NA	23685	-0.009	-0.3009	No
64	KCNJ8	NA	23698	-0.009	-0.3010	No
65	ABCF3	NA	23814	-0.009	-0.3029	No
66	PQBP1	NA	24018	-0.010	-0.3064	No
67	TARBP2	NA	24830	-0.015	-0.3210	No
68	IFNA4	NA	25409	-0.019	-0.3313	No
69	USP17L2	NA	25566	-0.020	-0.3337	No
70	IFNA2	NA	25696	-0.021	-0.3357	No
71	EIF2AK4	NA	26172	-0.024	-0.3439	No
72	SERINC3	NA	26570	-0.026	-0.3507	No
73	IFNA21	NA	26837	-0.028	-0.3550	No
74	SETD2	NA	27159	-0.030	-0.3603	No
75	VAMP8	NA	27162	-0.030	-0.3597	No
76	ZCCHC3	NA	28102	-0.036	-0.3762	No
77	FGL2	NA	28144	-0.037	-0.3762	No
78	PHB	NA	28323	-0.038	-0.3787	No
79	CLPB	NA	28616	-0.040	-0.3832	No
80	ISG20	NA	29159	-0.043	-0.3923	No
81	AZU1	NA	29511	-0.046	-0.3978	No
82	TRIM11	NA	29833	-0.048	-0.4027	No
83	C1QBP	NA	30118	-0.050	-0.4069	No
84	LYST	NA	30490	-0.053	-0.4127	No
85	OAS3	NA	30731	-0.054	-0.4159	No
86	IFNA17	NA	31580	-0.060	-0.4303	No
87	TRAF3IP1	NA	32057	-0.063	-0.4378	No
88	SIN3A	NA	32379	-0.066	-0.4423	No
89	IFNA6	NA	32909	-0.069	-0.4506	No
90	AKAP1	NA	33138	-0.071	-0.4533	No
91	POLR3G	NA	33189	-0.072	-0.4527	No
92	ZMPSTE24	NA	33358	-0.073	-0.4543	No
93	IFIT1B	NA	33479	-0.074	-0.4550	No
94	POLR3E	NA	33690	-0.075	-0.4573	No
95	PDE12	NA	33875	-0.077	-0.4591	No
96	ZNF175	NA	34110	-0.079	-0.4618	No
97	ZC3H12A	NA	34124	-0.079	-0.4604	No
98	POLR3B	NA	34203	-0.079	-0.4601	No
99	POLR3F	NA	34768	-0.083	-0.4688	No
100	IL23R	NA	34919	-0.085	-0.4698	No
101	IL4	NA	35114	-0.086	-0.4716	No
102	MMP12	NA	35155	-0.087	-0.4705	No
103	TRIM44	NA	36533	-0.098	-0.4938	No
104	IL21	NA	36539	-0.098	-0.4919	No
105	POLR3K	NA	36756	-0.100	-0.4938	No
106	BECN1	NA	36963	-0.101	-0.4955	No
107	NCBP3	NA	37356	-0.105	-0.5005	No
108	OASL	NA	37755	-0.108	-0.5056	No
109	BCL2L1	NA	38458	-0.114	-0.5161	No
110	ACOD1	NA	39040	-0.119	-0.5244	No
111	OAS1	NA	39387	-0.122	-0.5282	No
112	SERINC5	NA	39794	-0.126	-0.5330	No
113	IL27	NA	39948	-0.127	-0.5332	No
114	TRAF3IP2	NA	40076	-0.128	-0.5329	No
115	EXOSC5	NA	40581	-0.133	-0.5394	No
116	DNAJC3	NA	40791	-0.135	-0.5404	No
117	TLR9	NA	40935	-0.136	-0.5402	No
118	AGBL5	NA	41005	-0.137	-0.5387	No
119	DDIT4	NA	41272	-0.139	-0.5407	No
120	AICDA	NA	41283	-0.139	-0.5379	No
121	IFITM2	NA	41599	-0.143	-0.5408	No
122	ILF3	NA	41899	-0.146	-0.5433	No
123	RNF125	NA	41935	-0.146	-0.5409	No
124	IL6	NA	42171	-0.149	-0.5421	No
125	TSPAN6	NA	42361	-0.151	-0.5424	No
126	MICB	NA	42461	-0.152	-0.5411	No
127	POLR3C	NA	42720	-0.155	-0.5426	No
128	PPM1B	NA	42785	-0.155	-0.5406	No
129	NLRC5	NA	43075	-0.158	-0.5426	No
130	TOMM70	NA	43240	-0.160	-0.5423	No
131	PTPRC	NA	43514	-0.163	-0.5439	Yes
132	TRIM52	NA	43567	-0.164	-0.5415	Yes
133	IL2RA	NA	43652	-0.165	-0.5396	Yes
134	TICAM1	NA	43770	-0.166	-0.5383	Yes
135	APOBEC3B	NA	43868	-0.167	-0.5366	Yes
136	ELMOD2	NA	43961	-0.168	-0.5348	Yes
137	POLR3D	NA	43979	-0.169	-0.5316	Yes
138	NLRX1	NA	44148	-0.171	-0.5312	Yes
139	TNFAIP3	NA	44177	-0.171	-0.5281	Yes
140	F2RL1	NA	44408	-0.174	-0.5288	Yes
141	LILRB1	NA	44551	-0.175	-0.5277	Yes
142	POLR3A	NA	44813	-0.179	-0.5288	Yes
143	BIRC3	NA	44832	-0.179	-0.5254	Yes
144	IFI6	NA	45122	-0.183	-0.5269	Yes
145	NLRP1	NA	45127	-0.183	-0.5232	Yes
146	TTC4	NA	45482	-0.187	-0.5259	Yes
147	IFITM3	NA	45634	-0.189	-0.5247	Yes
148	CARD9	NA	45795	-0.191	-0.5237	Yes
149	ATG7	NA	45925	-0.193	-0.5220	Yes
150	PUM2	NA	45972	-0.194	-0.5188	Yes
151	IL12B	NA	45995	-0.194	-0.5152	Yes
152	ZMYND11	NA	46338	-0.199	-0.5174	Yes
153	TRIM34	NA	46692	-0.205	-0.5196	Yes
154	SEC14L1	NA	46774	-0.206	-0.5168	Yes
155	DHX9	NA	46818	-0.206	-0.5133	Yes
156	CNOT7	NA	46903	-0.207	-0.5106	Yes
157	ISG15	NA	46935	-0.208	-0.5068	Yes
158	RSAD2	NA	47065	-0.210	-0.5048	Yes
159	PTPN22	NA	47102	-0.210	-0.5011	Yes
160	ZDHHC11	NA	47279	-0.213	-0.5000	Yes
161	TRIM15	NA	47429	-0.215	-0.4982	Yes
162	IL10RB	NA	47608	-0.218	-0.4970	Yes
163	IFI16	NA	47877	-0.222	-0.4973	Yes
164	PLSCR1	NA	47913	-0.223	-0.4933	Yes
165	BNIP3L	NA	47943	-0.223	-0.4892	Yes
166	SLFN11	NA	47982	-0.224	-0.4853	Yes
167	DDX1	NA	48008	-0.224	-0.4811	Yes
168	ABCE1	NA	48171	-0.227	-0.4793	Yes
169	RIPK3	NA	48324	-0.229	-0.4774	Yes
170	TSPAN32	NA	48466	-0.232	-0.4751	Yes
171	MOV10	NA	48501	-0.232	-0.4709	Yes
172	IRF2	NA	48530	-0.233	-0.4666	Yes
173	SELENOK	NA	48567	-0.234	-0.4624	Yes
174	LSM14A	NA	48694	-0.236	-0.4598	Yes
175	ADARB1	NA	48752	-0.237	-0.4560	Yes
176	OAS2	NA	48826	-0.238	-0.4524	Yes
177	IFNAR2	NA	48962	-0.240	-0.4498	Yes
178	BCL2	NA	49021	-0.242	-0.4459	Yes
179	NT5C3A	NA	49078	-0.242	-0.4419	Yes
180	PUM1	NA	49114	-0.243	-0.4375	Yes
181	IL12RB1	NA	49241	-0.245	-0.4347	Yes
182	ITCH	NA	49266	-0.246	-0.4300	Yes
183	IFNL4	NA	49284	-0.246	-0.4252	Yes
184	SLFN13	NA	49364	-0.248	-0.4216	Yes
185	EIF2AK2	NA	49387	-0.248	-0.4168	Yes
186	MAP3K14	NA	49831	-0.258	-0.4196	Yes
187	UNC13D	NA	49937	-0.260	-0.4161	Yes
188	HERC5	NA	50033	-0.262	-0.4124	Yes
189	TRIM56	NA	50047	-0.262	-0.4072	Yes
190	HTRA1	NA	50444	-0.271	-0.4089	Yes
191	IFI44L	NA	50706	-0.277	-0.4080	Yes
192	DHX36	NA	50750	-0.278	-0.4030	Yes
193	IRF7	NA	51005	-0.284	-0.4017	Yes
194	IFNL3	NA	51111	-0.286	-0.3977	Yes
195	APOBEC3H	NA	51112	-0.286	-0.3918	Yes
196	MX1	NA	51226	-0.289	-0.3879	Yes
197	BNIP3	NA	51404	-0.294	-0.3850	Yes
198	DDX17	NA	51415	-0.294	-0.3791	Yes
199	IFIT1	NA	51436	-0.295	-0.3733	Yes
200	ZDHHC1	NA	51452	-0.296	-0.3674	Yes
201	CXCL10	NA	51482	-0.297	-0.3618	Yes
202	BST2	NA	51541	-0.298	-0.3567	Yes
203	IFNG	NA	51638	-0.300	-0.3522	Yes
204	BIRC2	NA	51639	-0.300	-0.3460	Yes
205	TRIM6	NA	51786	-0.305	-0.3423	Yes
206	AIMP1	NA	51856	-0.307	-0.3372	Yes
207	IFIT3	NA	52023	-0.312	-0.3338	Yes
208	MLKL	NA	52070	-0.313	-0.3281	Yes
209	USP15	NA	52232	-0.318	-0.3245	Yes
210	IFNL2	NA	52313	-0.321	-0.3193	Yes
211	FLNA	NA	52335	-0.322	-0.3130	Yes
212	DTX3L	NA	52427	-0.325	-0.3079	Yes
213	IFIT5	NA	52444	-0.326	-0.3014	Yes
214	ZBP1	NA	52472	-0.326	-0.2951	Yes
215	PRF1	NA	52475	-0.327	-0.2884	Yes
216	IFITM1	NA	52522	-0.328	-0.2824	Yes
217	SKP2	NA	52617	-0.332	-0.2772	Yes
218	DHX58	NA	52703	-0.334	-0.2719	Yes
219	IRF9	NA	52712	-0.335	-0.2651	Yes
220	PMAIP1	NA	52731	-0.336	-0.2584	Yes
221	MX2	NA	52778	-0.337	-0.2523	Yes
222	STAT1	NA	52795	-0.338	-0.2455	Yes
223	TRIM5	NA	52876	-0.341	-0.2399	Yes
224	IRF1	NA	52959	-0.344	-0.2343	Yes
225	RIOK3	NA	52987	-0.346	-0.2276	Yes
226	TBK1	NA	53174	-0.353	-0.2237	Yes
227	IFI27	NA	53187	-0.354	-0.2165	Yes
228	PARP9	NA	53342	-0.363	-0.2118	Yes
229	EXOC1	NA	53417	-0.366	-0.2056	Yes
230	AIM2	NA	53450	-0.368	-0.1985	Yes
231	CRCP	NA	53451	-0.368	-0.1909	Yes
232	APOBEC3F	NA	53628	-0.379	-0.1862	Yes
233	STAT2	NA	53669	-0.382	-0.1790	Yes
234	IFIH1	NA	53720	-0.385	-0.1719	Yes
235	RNASEL	NA	53901	-0.400	-0.1669	Yes
236	DDX60	NA	53952	-0.404	-0.1595	Yes
237	IFIT2	NA	53965	-0.406	-0.1512	Yes
238	CXCL9	NA	53980	-0.407	-0.1430	Yes
239	IFNA13	NA	54077	-0.417	-0.1361	Yes
240	PML	NA	54084	-0.419	-0.1276	Yes
241	IRF3	NA	54095	-0.420	-0.1190	Yes
242	IL33	NA	54180	-0.432	-0.1116	Yes
243	RTP4	NA	54182	-0.432	-0.1026	Yes
244	APOBEC3C	NA	54239	-0.439	-0.0945	Yes
245	CD40	NA	54257	-0.441	-0.0857	Yes
246	IL15	NA	54287	-0.444	-0.0770	Yes
247	APOBEC3G	NA	54303	-0.448	-0.0679	Yes
248	DDX58	NA	54348	-0.459	-0.0592	Yes
249	TLR3	NA	54368	-0.464	-0.0499	Yes
250	APOBEC3D	NA	54391	-0.470	-0.0406	Yes
251	GBP1	NA	54416	-0.475	-0.0311	Yes
252	TRIM22	NA	54536	-0.540	-0.0221	Yes
253	MICA	NA	54547	-0.553	-0.0108	Yes
254	GBP3	NA	54553	-0.558	0.0007	Yes