- General Drug Summary
- Drug Name
- Acetylsalicylic acid
- Description
- The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
- Also Known As
- 2-Acetoxybenzenecarboxylic acid; 2-Acetoxybenzoic acid; 2-Carboxyphenyl acetate; A.S.A.; Acetilsalicilico; Acetilum acidulatum; Acetosalic acid; Acetoxybenzoic acid; Acetylsalicylate; Acetylsalicylsaure (GERMAN); Acetysalicylic acid; Acide acetylsalicylique (FRENCH); Acido acetilsalicilico; Acido O-acetil-benzoico; Acidum acetylsalicylicum; ASA; Kyselina 2-acetoxybenzoova; Kyselina acetylsalicylova; O-accetylsalicylic acid; o-Acetoxybenzoic acid; O-Acetylsalicylic acid; o-Carboxyphenyl acetate; Salicylic acid acetate; Salicylic acid, acetate
- Structure
- Summary In Neonatal Jaundice
-
1 record(s) for Acetylsalicylic acid NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 626518
- Acetylsalicylic acid
- NA
- NA
- Summary
-
- Factors influencing jaundice in immigrant Greek infants. Archives of disease in childhood, 1978 Jan [Go to PubMed]
- A study of 887 consecutively born immigrant Greek and 220 Anglo-Saxon Australian infants has shown that serum bilirubin concentrations are influenced by these factors: breast feeding, delivery with forceps, gestation, birthweight, sex of the infant, presence of hypoxia, presence of blood group incompatibility, a positive direct Coombs's test, maternal sepis, and administration to the mother of promethazine hydrochloride, reserpine, chloral hydrate, barbiturates, narcotic agents, diazepam, oxytocin, aspirin, and phenytoin sodium. Apart from the administration of promethazine hydrochloride, reserpine, chloral hydrate, and quinalbarbitone sodium, only two factors, breast feeding and delivery by forceps, occured with different frequencies in the immigrant Greek and the Australian infants. Among the Greek infants with jaundice, there were few where the cause of the jaundice was inapparent. The immigrant Greek and Australian newborn populations were therefore remarkably similar. Since differences of frequency and everity of jaundice do exist in infants born in Greece, this difference must be lost when the parents emigrate, and therefore an environmental factor must be incriminated as the causative agent for jaundice of unknown origin in Greece.
-
2 record(s) for Acetylsalicylic acid Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 957015
- Acetylsalicylic acid
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Administration of narcotic agents, barbiturates, aspirin, chloral hydrate, reserpine, and phenytoin sodium all resulted in lowering of infant serum bilirubin concentrations.
- The effect of maternally administered drugs on bilirubin concentrations in the newborn infant. The Journal of pediatrics, 1976 Oct [Go to PubMed]
- The effects of drugs administered to pregnant women on bilirubin concentrations in 1,107 consecutively born infants are presented. Administration of narcotic agents, barbiturates, aspirin, chloral hydrate, reserpine, and phenytoin sodium all resulted in lowering of infant serum bilirubin concentrations. Diazepam and, to a lesser extent, oxytocin caused an elevation of infant serum bilirubin concentrations. Although many drugs were shown to alter serum bilirubin levels significantly, the clinical importance of such alterations was not dramatic except possibly in special circumstances. The phenothiazine derivatives, general or local anesthesia, sulfadimidine, ampicillin, and penicillin had no such effect on the newborn infant when given to the mother before delivery.
- 1130188
- Acetylsalicylic acid
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Administration of narcotic agents, barbiturates, aspirin, chloral hydrate, reserpine, and phenytoin sodium all resulted in lowering of infant serum bilirubin concentrations.
- Studies on photopherapy in newborn infants. Influence on protein binding of bilirubin and salicylate and on activity of acetylsalicylic acid esterase. Acta paediatrica Scandinavica, 1975 Mar [Go to PubMed]
- Phototherapy of newborn infants with hyperbilirubinemia was shown to result in an increase in hematocrit values and in the activity of the erythrocyte enzyme acetylsalicylic acid esterase. The elevation of the enzyme activity also could be produced in light-treated rabbits and in vitro after illumination of blood from adult volunteers. The binding of bilirubin to serum albumin and of salicylate to plasma proteins did not alter, nor did the concentrations of albumin or total proteins in plasma. It is concluded that light does not increase the unbound fraction of bilirubin in blood.