- General Drug Summary
- Description
- Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized. [PubChem]
- Also Known As
- 17beta oestradiol; 17; β; -estra-1,3,5(10)-triene-3,17-diol; 17; β; -estradiol; 17; β; -oestradiol; beta-Estradiol; cis-estradiol; Estradiol-17beta
- Categories
- Anti-menopausal Agen
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Estradiol NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 878542
- Estradiol
- NA
- Clinical Trial
- Summary
- The amount of estradiol and estradiol to be eliminated may not attached to etiologic importance,and icteric newborns have a relative insufficiency in estradiol elimination.
- [Bilirubin level and estrogen elimination in newborns (author's transl)]. Zeitschrift für Geburtshilfe und Perinatologie, 1977 Apr [Go to PubMed]
- Free estradiol and estriol was determined radioimmunologically in cord blood and in peripheral venous blood during the third, fifth and seventh day of life. The steroid level of a group of children with icterus neonatorum simplex were compared with an anicteric control group. In spite of the higher level of estriol in cord blood during the first week of life, estriol was eliminated much more rapidly than estradiol and independent of the bilirubin level. Given the same initial values for estradiol in cord blood of both control groups, the estradiol elimination rate was significantly slower in icteric newborns. The level of estradiol in cord blood was significantly higher in newborn males than in newborn females. A higher level in cord blood, however, does not increase the risk of a later newborn hyperbilirubinemia. Our findings tend to indicate that no etiologic importance should be attached to the amount of estradiol and estradiol to be eliminated, for the development of icterus neonatorum simplex. At the sae time, icteric newborns have a relative insufficiency in estradiol elimination but not, however, in estriol elimination.