- PMID
- Gene Name
- Molecular Event
- Function in UC
- 20022574
- SLCO1B1
- polymorphism
- Diagnosis; Pathogenesis
- Method
- NA
- Summary
- ADD A NOTE
- Exploring the genetic architecture of neonatal hyperbilirubinemia. neonatal medicine, 2010 Jun [Go to PubMed]
- The potential for genetic variation to modulate neonatal hyperbilirubinemia risk is increasingly being recognized. In particular, polymorphisms across three genes involved in bilirubin production and metabolism [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia. Variant gene co-expression including compound and synergistic heterozygosity enhances hyperbilirubinemia risk, contributing to the etiologic heterogeneity and complex nature of neonatal jaundice.
1 pubmed articles have reported SLCO1B1 polymorphism associated with Neonatal Jaundice.