The pandemic of COVID-19 raised severe challenges for clinical treatment and prognosis and previous work revealed the response of different patients to COVID-19 are diverse, along with age, sex, and other factors. To better explore the involvement of aging on the response to COVID-19 in the whole body, we presented annotated information about SARS-CoV-2-associated genes and calculated the total number of samples which was statistically significant (p-adj < 0.05 and |Log2FC|> 1) in contrastive age groups and different tissues.